Director's Overview: Project Summary/Abstract The UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC) seeks to reduce cancer incidence, mortality, and morbidity in its Northern California catchment area, nationally, and globally. The principles of precision cancer medicine and precision population health systematically and intimately link research and clinical service delivery for patient and population benefit. The HDFCCC builds on the richness of the basic biological insights and the extensive and exceptional clinical research and facilities at UCSF, one of the world's leading health research universities. Moreover, its location in the San Francisco Bay Area allows the HDFCCC to take advantage of one of the most culturally diverse populations and highly innovative and intellectually vibrant environments in the world. This is accomplished through the ten Research Programs supported by seven Shared Resources and clinical and administrative infrastructure.